The San Diego Padres and the Minnesota Twins will kick off a three-game series at 9:40 p.m. ET on Friday at Petco Park. After six games on the road, the Padres are heading back home.

On Wednesday, the Padres didn’t have quite enough to beat the Mets and fell 4-2. Michael King was a force to be reckoned with on the mound despite the final result: He pitched 6.2 innings while giving up two earned runs off four hits.

At the plate, the Padres saw five different players step up and record at least one hit. One of them was Fernando Tatis, who went 1-for-3 while logging a double and one RBI. Tatis has been coming through with runners on lately: He’s racked up 10 RBIs in his last 10 games compared to 51 in his previous 116 games.

Meanwhile, the home team had won the previous five meetings between the Twins and the Braves, and the Twins kept the tradition alive on Wednesday. They had just enough and edged out the Braves 6-4. The victory is more of the same for Minnesota, who have now won three contests in a row.

Taj Bradley tossed a big game, striking out seven batters over five innings while giving up just one earned run off two hits. He had some trouble finding his footing against the Phillies last Thursday, so this was a nice turnaround.

San Diego is now 68-60, having gone 2-3 since its six-game winning streak ended. As for Minnesota, the Twins’ victory brought them up to 63-65. The Padres couldn’t quite get it done against Minnesota when the teams last played on August 31, 2025, as they fell 7-2. Will the Padres have more luck at home instead of on the road?

How to Watch Minnesota Twins at San Diego Padres

• Date: Aug. 21, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park
• TV: Twins.TV
• Streaming: Stream on Fubo
• Buy tickets: Buy Twins at Padres tickets on Ticketmaster

Probable Starting Pitcher Analysis

Randy Vásquez (SD)

2026 Season Stats: 8-6 | 4.30 ERA | 1.38 WHIP | 5.8 K/9

• Won last start on Aug. 9 vs. HOU- 5 IP, 2 ER, 2 H
• 2-2, 5.65 ERA in last 10 appearances; 6-4, 3.63 ERA in prior 14 games
• 2.6 walks per nine innings this season; 3.5 last season

Connor Prielipp (MIN)

2026 Season Stats: 3-6 | 5.34 ERA | 1.38 WHIP | 9.7 K/9

• Lost last start on Aug. 15 vs. PHI- 5 IP, 8 ER, 8 H
  • 8 earned runs – new career-high
• 8.22 earned run average in last three starts; 4.73 earned run average in prior 14 games
• Pitching with five days rest

Minnesota Twins vs. San Diego Padres Betting Odds

• Moneyline: MIN +106 / SD -116
• Run line: SD -1.5
• Over/Under: 8

Betting lines as of 08/21/2026 at 8:27 AM ET. Odds subject to change. Bet with bet365.

Minnesota Twins Stat Check: Who’s Hot, Who’s Not

Who’s Hot

• Josh Bell (MIN): 5-10, 2 2B, 5 RBIs, and 3 R in last three games; .253/.315/.420 in prior 120 games

Who’s Not

• Trevor Larnach (MIN) Previous Game: 0-3, 2 K
  • 0 extra-base hits in 11 straight games
• Victor Caratini (MIN): 0 extra-base hits in 18 straight games
• Tristan Gray (MIN): .156/.194/.172 since Jun. 9; .266/.308/.413 in prior 39 games

San Diego Padres Stat Check: Who’s Hot, Who’s Not

Who’s Hot

• Gavin Sheets (SD): 3-7, 2 RBIs in last three games; .210/.312/.388 in prior 114 games

Who’s Not

• Manny Machado (SD): .250/.312/.318 since Aug. 8; .211/.298/.423 in prior 114 games
  • Previous Game: 0-4, 3 K
• Jackson Merrill (SD): 1-12 in last three games; .244/.295/.416 in prior 121 games
  • Previous Game: 0-4, 2 K
• Sung-Mun Song (SD) Previous Game: 0-3
  • 1-8 in last four games; .208/.317/.274 in prior 45 games

Last 10 Games for Minnesota Twins (5-5)

• Aug. 19: W vs. ATL 6-4
• Aug. 18: W vs. ATL 4-1
• Aug. 17: W vs. ATL 4-2
• Aug. 16: L vs. PHI 5-7
• Aug. 15: L vs. PHI 1-9
• Aug. 13: L vs. PHI 1-7
• Aug. 12: W vs. BAL 7-5
• Aug. 11: L vs. BAL 2-5
• Aug. 10: W vs. BAL 9-5
• Aug. 9: L @ MIL 3-4

Last 10 Games for San Diego Padres (7-3)

• Aug. 19: L @ NYM 2-4
• Aug. 18: W @ NYM 5-2
• Aug. 17: L @ NYM 1-2
• Aug. 16: W @ CLE 5-0
• Aug. 15: L @ CLE 1-6
• Aug. 14: W @ CLE 7-5
• Aug. 12: W vs. MIL 4-3
• Aug. 11: W vs. MIL 11-2
• Aug. 10: W vs. MIL 3-2
• Aug. 9: W vs. HOU 7-2

Final Score Prediction for Minnesota Twins @ San Diego Padres on Aug. 21, 2026

Twins 4 – Padres 6

Lean: Padres

No reason to fight the board here. We’ll take the Padres as we don’t see Connor Prielipp righting the ship here.

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