New York Mets at Chicago White Sox MLB Prediction, Picks & Odds for Aug. 21, 2026

New York Mets at Chicago White Sox MLB Prediction, Picks & Odds for Aug. 21, 2026

A comprehensive preview, including betting odds and predictions, for the MLB game between the New York Mets and the Chicago White Sox on Aug. 21, 2026.

Athlon Sports News Desk
6d ago
New York Mets at Chicago White Sox MLB Prediction, Picks & Odds for Aug. 21, 2026

The Chicago White Sox are 2-10 against the New York Mets over the past two years, but they’ll have a chance to close the gap Friday. The White Sox will open a three-game series against the Mets at 7:40 p.m. ET at Rate Field.

Thursday just wasn’t the day for the White Sox’s offense. They fell just short of the Braves, 2-0. The home team had earned the win in each of the previous four meetings, but that streak is no more.

Anthony Kay was a force to be reckoned with on the mound despite the final result: he struck out six batters over six innings while giving up two earned runs off five hits (and only one walk).

Perhaps unsurprisingly given the score, the White Sox didn’t exactly tear the cover off the ball and finished the game with only one hit. They have not posted that few hits since June 13, when they also had one.

Meanwhile, the Mets snuck past the Padres with a 4-2 victory on Wednesday.

Robert Stock tossed a big game, striking out six batters over 4.1 innings while giving up just one earned run off two hits. Those six batters struck out set a new season-high mark for him.

At the plate, the Mets saw five different players step up and record at least one hit. One of them was Carson Benge, who went 2-for-4 while logging a homer and two RBIs. Benge has been locked in at the plate lately: he’s hit .356 over his last 12 games vs .263 in his previous 109 games.

New York has been on a roll lately: the Mets have won five of their last six contests. That’s provided a bump to their 58-70 record this season. As for the White Sox, they have now lost three of their last four games at home. That’s taken a bite out of their 66-61 record this season.

Chicago was able to grind out a solid win over New York in the teams’ previous matchup on May 28, 2025, winning 9-4. Will the White Sox repeat their success, or do the Mets have a better game plan this time around? We’ll find out soon enough.

How to Watch New York Mets at Chicago White Sox

  • Date: August 21, 2026
  • Time: 7:40 p.m. ET
  • Venue: Rate Field
  • TV: Chicago Sports Network
  • Streaming: Stream on Fubo
  • Buy tickets: Buy Mets at White Sox tickets on Ticketmaster

Probable Starting Pitcher Analysis

Sean Burke (CWS)

2026 Season Stats: 7-6 | 3.15 ERA | 1.11 WHIP | 9.9 K/9

  • No decision in last start on August 16 @ DET- 4.1 IP, 4 ER, 5 H
    • Two batters struck out – fewest since April 15
  • 2.7 walks per nine innings this season; 4.2 last season

Sean Manaea (NYM)

2026 Season Stats: 4-5 | 4.22 ERA | 1.32 WHIP | 9.2 K/9

  • No decision in last start on August 15 vs. WSH- 6.1 IP, 4 ER, 6 H
  • 2-0, 2.87 ERA in last five starts; 2-5, 4.74 ERA in prior 21 games
  • 3.0 walks per nine innings this season; 1.8 last season
  • Last start vs CWS (September 1, 2024, road): (ND) 7 IP, 0 ER, 2 H

New York Mets vs. Chicago White Sox Betting Odds

  • Moneyline: NYM +125 / CWS -150
  • Run line: CWS -1.5
  • Over/Under: 8

Betting lines as of 08/21/2026 at 8:28 AM ET. Odds subject to change. Bet with bet365.

New York Mets Stat Check: Who’s Hot, Who’s Not

Who’s Hot

  • Luis Torrens (NYM): .417/.500/1.042 in last nine games; .223/.287/.324 in prior 64 games
  • Bo Bichette (NYM): 1+ time on base in 10 straight games
  • Jared Young (NYM): .370/.388/.587 since Aug. 5; .244/.325/.411 in prior 63 games

Who’s Not

  • Francisco Alvarez (NYM) Previous Game: 0-4
    • 0-10 in last three games; .248/.338/.428 in prior 85 games
  • A.J. Ewing (NYM): 0 extra-base hits in eight straight games
  • Eric Wagaman (NYM): .150/.227/.150 in last eight games; .227/.320/.500 in prior 13 games

Chicago White Sox Stat Check: Who’s Hot, Who’s Not

Who’s Hot

  • No players currently match our analysis around current trends.

Who’s Not

  • Munetaka Murakami (CWS): .162/.288/.441 since Aug. 1; .244/.382/.553 in prior 74 games
    • Previous Game: 0-4
  • Chase Meidroth (CWS): .130/.167/.130 in last six games; .280/.356/.421 in prior 116 games
    • Previous Game: 0-3
  • Sam Antonacci (CWS): .059/.304/.059 in last five games; .278/.367/.409 in prior 101 games
    • Previous Game: 0-4

Last 10 Games for New York Mets (7-3)

  • Aug. 19: W vs. SD 4-2
  • Aug. 18: L vs. SD 2-5
  • Aug. 17: W vs. SD 2-1
  • Aug. 16: W vs. WSH 4-3
  • Aug. 15: W vs. WSH 5-4
  • Aug. 14: W vs. WSH 4-1
  • Aug. 12: L @ ATL 3-6
  • Aug. 11: L @ ATL 0-4
  • Aug. 10: W @ ATL 8-5
  • Aug. 9: W @ PIT 11-1

Last 10 Games for Chicago White Sox (5-5)

  • Aug. 20: L vs. ATL 0-2
  • Aug. 19: W @ CHC 3-0
  • Aug. 18: L @ CHC 3-4
  • Aug. 17: L @ CHC 5-7
  • Aug. 16: W @ DET 7-5
  • Aug. 15: W @ DET 4-3
  • Aug. 14: W @ DET 9-5
  • Aug. 13: L vs. CIN 8-9
  • Aug. 12: W vs. CIN 5-0
  • Aug. 11: L vs. CIN 4-5

Final Score Prediction for New York Mets @ Chicago White Sox on August 21, 2026

Mets 3 – White Sox 5

Lean: White Sox

We’re with the oddsmakers on this one and like the White Sox to cover, and we think this lineup is a better mix for Sean Burke than his last start suggests.

Disclosure: Some or all of this content may have been generated by AI. While we strive for accuracy, AI can occasionally produce incorrect information. If you buy something via one of our links, we may earn a commission.

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