Tampa Bay Rays at Baltimore Orioles MLB Prediction, Picks & Odds for Aug. 21, 2026
A comprehensive preview, including betting odds and predictions, for the MLB game between the Tampa Bay Rays and the Baltimore Orioles on Aug. 21, 2026.

The Baltimore Orioles and Tampa Bay Rays will start a three-game series at 7:15 p.m. ET Friday at Camden Yards. The timing isn’t great for Baltimore: the O’s have been struggling with four straight losses at home, while Tampa Bay has snatched up nine consecutive wins on the road.
The Orioles will face the Rays after dropping another game against the Yankees on Thursday, falling 6-1.
The Orioles saw three different players step up and record at least one hit. One of them was Dylan Beavers, who went 1-for-3 with a homer. Beavers has been locked in at the plate lately: he’s hit .266 over his last 32 games vs .218 in his previous 39 games.
Meanwhile, the Rays couldn’t handle the Blue Jays on Thursday and fell 5-1.
Baltimore has now lost six of its last eight games at home. That’s put a noticeable dent in the Orioles’ 61-67 record this season. As for Tampa Bay, the Rays have also now lost six of their last eight games at home. That’s done some real damage to their 76-51 record this season.
How to Watch Tampa Bay Rays at Baltimore Orioles
- Date: August 21, 2026
- Time: 7:15 p.m. ET
- Venue: Oriole Park at Camden Yards
- TV: Apple TV+
- Streaming: Stream on Fubo
- Buy tickets: Buy Rays at Orioles tickets on Ticketmaster
Probable Starting Pitcher Analysis
Trevor Rogers (BAL)
2026 Season Stats: 8-8 | 4.15 ERA | 1.25 WHIP | 7.7 K/9
- Won last start on August 16 @ TB- 6 IP, 2 ER, 7 H
- 6-2, 2.71 ERA since May. 29; 2-6, 6.96 ERA in prior nine games
- 4.15 earned run average this season; 1.81 last season
Freddy Peralta (TB)
2026 Season Stats: 5-10 | 5.27 ERA | 1.48 WHIP | 8.6 K/9
- Lost last start on August 16 vs. BAL- 4.2 IP, 2 ER, 1 H
- 0-5, 7.80 ERA in last 10 starts; 5-5, 3.90 ERA in prior 15 games
- High run support: 7.0 per game this season with TB
Tampa Bay Rays vs. Baltimore Orioles Betting Odds
- Moneyline: TB +111 / BAL -132
- Run line: BAL -1.5
- Over/Under: 8.5
Betting lines as of 08/21/2026 at 8:28 AM ET. Odds subject to change. Bet with bet365.
Tampa Bay Rays Stat Check: Who’s Hot, Who’s Not
Who’s Hot
- Yandy Díaz (TB): 1+ time on base in 11 straight games
- Chandler Simpson (TB): 1+ time on base in 11 straight games
- Taylor Walls (TB): .345/.367/.552 in last nine games; .211/.303/.276 in prior 89 games
Who’s Not
- Jonny DeLuca (TB): .125/.176/.125 in last six games; .273/.304/.454 in prior 68 games
- Previous Game: 0-4
- Jorge Mateo (TB) Previous Game: 0-3
- 2-11 in last four games; .244/.289/.386 in prior 51 games
- Nick Fortes (TB) Previous Game: 0-3
- .067/.176/.067 in last six games; .278/.319/.386 in prior 80 games
Baltimore Orioles Stat Check: Who’s Hot, Who’s Not
Who’s Hot
- Tyler O’Neill (BAL): .279/.354/.581 since Jul. 1; .182/.282/.270 in prior 49 games
- Pete Alonso (BAL): .500/.571/.952 since Aug. 9; .247/.340/.454 in prior 117 games
- Gunnar Henderson (BAL): .353/.450/.647 in last nine games; .212/.293/.382 in prior 118 games
Who’s Not
- Jeremiah Jackson (BAL): 0 hits in 14 straight games
- Christian Encarnacion-Strand (BAL): 0-8 in last three games; .272/.310/.543 in prior 24 games
- Previous Game: 0-4, 2 K
- Colton Cowser (BAL) Previous Game: 0-3, 2 K
- No times on base in four straight games
Last 10 Games for Tampa Bay Rays (5-5)
- Aug. 20: L vs. TOR 1-5
- Aug. 19: W vs. TOR 7-6
- Aug. 18: L vs. TOR 5-10
- Aug. 17: W vs. BAL 7-6
- Aug. 16: L vs. BAL 2-10
- Aug. 15: L vs. BAL 3-4
- Aug. 14: L vs. BAL 5-6
- Aug. 12: W @ ATH 8-4
- Aug. 11: W @ ATH 12-4
- Aug. 10: W @ ATH 10-6
Last 10 Games for Baltimore Orioles (4-6)
- Aug. 20: L vs. NYY 1-6
- Aug. 19: L vs. NYY 3-5
- Aug. 18: L vs. NYY 1-3
- Aug. 17: L @ TB 6-7
- Aug. 16: W @ TB 10-2
- Aug. 15: W @ TB 4-3
- Aug. 14: W @ TB 6-5
- Aug. 12: L @ MIN 5-7
- Aug. 11: W @ MIN 5-2
- Aug. 10: L @ MIN 5-9
Final Score Prediction for Tampa Bay Rays @ Baltimore Orioles on August 21, 2026
Rays 5 – Orioles 4
Lean: Rays
That’s a slight lean against the line, but we like the Rays in this one with Yandy Díaz swinging it the way he has been.
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