Cleveland Guardians at Colorado Rockies MLB Prediction, Picks & Odds for Aug. 21, 2026
A comprehensive preview, including betting odds and predictions, for the MLB game between the Cleveland Guardians and the Colorado Rockies on Aug. 21, 2026.

The Cleveland Guardians and the Colorado Rockies will kick off a three-game series at 8:40 p.m. at Coors Field on Friday. The Guardians will have to hit the road after six straight games at home. Cleveland will be strutting in after a victory, while Colorado will be stumbling in from a defeat.
On Thursday, the Guardians beat the Giants 5-2. The Guardians received a great performance from Gavin Williams as he struck out 11 batters over 5.2 innings while giving up two earned runs off four hits. Williams had some trouble finding his footing against the Padres last Friday, so this was a step in the right direction.
At the plate, the Guardians’ win was truly a team effort as eight different players contributed at least one hit. One of them was Patrick Bailey, who went 2-for-3 while posting a stolen base, one RBI, and a run. Bailey has been driving the ball out of the park lately: He’s hit four home runs in his last 25 games compared to two in his previous 57 games.
Meanwhile, the Rockies fought the good fight in their extra-innings contest against the Dodgers on Wednesday but wound up with a less-than-desirable result. They fell just short of the Dodgers by a score of 6-4. Colorado’s loss continues a disappointing trend for the team, making it three in a row.
Mickey Moniak made the most of his time in the batter’s box despite the final result and went 3-for-5 while logging one home run, two RBIs, and a double. Those three hits were his most since July 2.
Cleveland’s victory bumped its record up to 62-66. As for Colorado, the Rockies’ defeat dropped their record down to 50-77. Cleveland was able to grind out a solid win over Colorado when the teams last played on July 30, 2025, winning 5-0. The rematch might be a little tougher for the Guardians since the squad won’t have the home-field advantage this time around. We’ll see if the change in venue makes a difference.
How to Watch Cleveland Guardians at Colorado Rockies
- Date: Aug. 21, 2026
- Time: 8:40 p.m. ET
- Venue: Coors Field
- TV: Rockies.TV
- Streaming: Stream on Fubo
- Buy tickets: Buy Guardians at Rockies tickets on Ticketmaster
Probable Starting Pitcher Analysis
Joey Cantillo (CLE)
2026 Season Stats: 9-7 | 3.80 ERA | 1.44 WHIP | 10.0 K/9
- Won last start on Aug. 15 vs. SD- 6 IP, 1 ER, 1 H
- 8.7 hits allowed per nine innings this season; 7.4 last season
- Pitching with five days rest
Tanner Gordon (COL)
2026 Season Stats: 0-3 | 5.55 ERA | 1.44 WHIP | 7.8 K/9
- No decision in last start on Aug. 15 @ SF- 4 IP, 0 ER, 3 H
- 3.12 earned run average in last six appearances; 6.95 earned run average in prior 11 games
- Last start vs CLE (July 29, 2025, road): (L) 3 IP, 6 ER, 8 H
Cleveland Guardians vs. Colorado Rockies Betting Odds
- Moneyline: CLE -160 / COL +133
- Run line: CLE -1.5
- Over/Under: 10.5
Betting lines as of 08/21/2026 at 8:28 AM ET. Odds subject to change. Bet with bet365.
Cleveland Guardians Stat Check: Who’s Hot, Who’s Not
Who’s Hot
- Kyle Manzardo (CLE): .312/.450/.750 in last six games; .209/.298/.358 in prior 96 games
Who’s Not
- Angel Martínez (CLE): 0 walks in 12 straight games
- Jo Adell (CLE): .175/.273/.404 since July 31; .244/.291/.403 in prior 108 games
- David Fry (CLE): 0 hits in 14 straight games
Colorado Rockies Stat Check: Who’s Hot, Who’s Not
Who’s Hot
- Brett Sullivan (COL): .280/.367/.680 in last nine games; .231/.268/.399 in prior 52 games
Who’s Not
- Troy Johnston (COL): .149/.203/.209 since July 6; .313/.383/.434 in prior 82 games
- Mickey Moniak (COL): .195/.239/.317 since Aug. 5; .278/.318/.574 in prior 76 games
- Cole Carrigg (COL): 2-14 in last three games; .292/.378/.486 in prior 53 games
Last 10 Games for Cleveland Guardians (4-6)
- Aug. 20: W vs. SF 5-2
- Aug. 19: L vs. SF 0-1
- Aug. 18: W vs. SF 8-1
- Aug. 16: L vs. SD 0-5
- Aug. 15: W vs. SD 6-1
- Aug. 14: L vs. SD 5-7
- Aug. 13: L @ DET 0-3
- Aug. 12: W @ DET 6-4
- Aug. 11: L @ DET 4-6
- Aug. 9: L @ CWS 3-5
Last 10 Games for Colorado Rockies (4-6)
- Aug. 19: L vs. LAD 4-6
- Aug. 18: L vs. LAD 6-7
- Aug. 17: L vs. LAD 5-11
- Aug. 16: W @ SF 13-7
- Aug. 15: L @ SF 1-7
- Aug. 14: W @ SF 5-2
- Aug. 12: W @ AZ 6-4
- Aug. 11: W @ AZ 3-2
- Aug. 10: L @ AZ 0-9
- Aug. 9: L @ STL 4-7
Final Score Prediction for Cleveland Guardians @ Colorado Rockies on Aug. 21, 2026
Guardians 6 – Rockies 5
Lean: Guardians
The run line is the tricky part here, but we have the Guardians winning it, as we don’t think this matchup looks good for Tanner Gordon.
Disclosure: Some or all of this content may have been generated by AI. While we strive for accuracy, AI can occasionally produce incorrect information. If you buy something via one of our links, we may earn a commission.